Predictors of treatment switching in the Big Multiple Sclerosis Data Network
Spelman, T., Magyari, M., Butzkueven, H., Van Der Walt, A., Vukusic, S., Trojano, M., Iaffaldano, P., Horáková, D., Drahota, J., Pellegrini, F., et al. (2023). Front Neurol (14). p.1274194

Comparison of 2 Methods for Estimating Multiple Sclerosis-Related Mortality
Rollot, F., Uhry, Z., Dantony, E., Vukusic, S., Debouverie, M., Le Page, E., Ciron, J., Ruet, A., De Sèze, J., Zéphir, H., et al. (2023). Neurology (101). p.e2483–e2496

The biological sample collection of the OFSEP French MS registry: An essential tool dedicated to researchers
Brocard, G., Casey, R., Dufay, N., Marignier, R., Michel, L., Hisbergues, M., Ayrignac, X., Lehmann, S., Thouvenot, E., Gallot, G., et al. (2023). Multiple Sclerosis and Related Disorders (77). p.104872

Rituximab De-escalation in Patients With Neuromyelitis Optica Spectrum Disorder
Demuth, S., Collongues, N., Audoin, B., Ayrignac, X., Bourre, B., Ciron, J., Cohen, M., Deschamps, R., Durand-Dubief, F., Maillart, E., et al. (2023). Neurology (101). p.e438–e450

A study on loss functions and decision thresholds for the segmentation of multiple sclerosis lesions on spinal cord MRI
Hussein, B.R., Meurée, C., Gaubert, M., Masson, A., Kerbrat, A., Combès, B., and Galassi, F. (2023). A study on loss functions and decision thresholds for the segmentation of multiple sclerosis lesions on spinal cord MRI. In 20th IEEE International Symposium on Biomedical Imaging (ISBI 2023), (Cartagena (Colombia), Colombia), p.

Investigating the Long-term Effect of Pregnancy on the Course of Multiple Sclerosis Using Causal Inference
Gavoille, A., Rollot, F., Casey, R., Debouverie, M., Le Page, E., Ciron, J., De Seze, J., Ruet, A., Maillart, E., Labauge, P., et al. (2023). Neurology (100). p.e1296–e1308

The radiologically isolated syndrome: revised diagnostic criteria
Lebrun-Frénay, C., Okuda, D.T., Siva, A., Landes-Chateau, C., Azevedo, C.J., Mondot, L., Carra-Dallière, C., Zephir, H., Louapre, C., Durand-Dubief, F., et al. (2023). Brain p.awad073

Pregnancy and post-partum in patients with myelin-oligodendrocyte glycoprotein antibody-associated disease
Carra-Dallière, C., Rollot, F., Deschamps, R., Ciron, J., Vukusic, S., Audoin, B., Ruet, A., Maillart, E., Papeix, C., Zephir, H., et al. (2023). Mult Scler (29). p.270–276

Heterogeneity on long-term disability trajectories in patients with secondary progressive MS: a latent class analysis from Big MS Data network
Signori, A., Lorscheider, J., Vukusic, S., Trojano, M., Iaffaldano, P., Hillert, J., Hyde, R., Pellegrini, F., Magyari, M., Koch-Henriksen, N., et al. (2023). J Neurol Neurosurg Psychiatry (94). p.23–30

Effects of socioeconomic status on excess mortality in patients with multiple sclerosis in France: A retrospective observational cohort study
Wilson, S., Calocer, F., Rollot, F., Fauvernier, M., Remontet, L., Tron, L., Vukusic, S., Le Page, E., Debouverie, M., Ciron, J., et al. (2023). Lancet Reg Health Eur (24). p.100542

Proportion and characteristics of secondary progressive multiple sclerosis in five European registries using objective classifiers
Forsberg, L., Spelman, T., Klyve, P., Manouchehrinia, A., Ramanujam, R., Mouresan, E., Drahota, J., Horakova, D., Joensen, H., Pontieri, L., et al. (2023). Mult Scler J Exp Transl Clin (9). p.20552173231153556

Real-life study to assess effectiveness and safety of eculizumab in patients with neuromyelitis optica spectrum disorders in France: protocol for ECUP4, an observational study
Marignier, R., Laplaud, D., Zéphir, H., Papeix, C., Leray, E., Amri, E., Piotaix, M., and de Sèze, J. (2023). Front Neurol (14). p.1303874

Disease-modifying treatment and disability progression in subclasses of patients with primary progressive MS: results from the Big MS Data Network
Lorscheider, J., Signori, A., Subramaniam, S., Benkert, P., Vukusic, S., Trojano, M., Hillert, J., Glaser, A., Hyde, R., Spelman, T., et al. (2024). J Neurol Neurosurg Psychiatry p.jnnp-2024-334700

Association between education level and disability progression in patients with multiple sclerosis in France
Lefort, M., Dejardin, O., Berger, E., Camdessanché, J.-P., Ciron, J., Clavelou, P., De Sèze, J., Debouverie, M., Heinzlef, O., Labauge, P., et al. (2024). Mult Scler p.13524585241289274

Anti-CD20 Therapies in Drug-Naive Patients With Primary Progressive Multiple Sclerosis: A Multicenter Real-Life Study
Hay, M., Rollot, F., Casey, R., Kerbrat, A., Edan, G., Mathey, G., Labauge, P., De Sèze, J., Vukusic, S., Laplaud, D.-A., et al. (2024). Neurology (103). p.e209886

Early Maintenance Treatment Initiation and Relapse Risk Mitigation After a First Event of MOGAD in Adults: The MOGADOR2 Study
Deschamps, R., Guillaume, J., Ciron, J., Audoin, B., Ruet, A., Maillart, E., Pique, J., Benyahya, L., Laplaud, D.A., Michel, L., et al. (2024). Neurology (103). p.e209624

Acute Clinical Events Identified as Relapses With Stable Magnetic Resonance Imaging in Multiple Sclerosis
Gavoille, A., Rollot, F., Casey, R., Kerbrat, A., Le Page, E., Bigaut, K., Mathey, G., Michel, L., Ciron, J., Ruet, A., et al. (2024). JAMA Neurology

The diagnostic workup of children with the radiologically isolated syndrome differs by age and by sex
Makhani, N., Lebrun-Frenay, C., Siva, A., Shabanova, V., Wassmer, E., Santoro, J.D., Narula, S., Brenton, J.N., Mar, S., Durand-Dubief, F., et al. (2024). J Neurol (271). p.4019–4027

Framework for personalized prediction of treatment response in relapsing-remitting multiple sclerosis: a replication study in independent data
Sakr, A.M., Mansmann, U., Havla, J., Ön, B.I., and Ön, B.I. (2024). BMC Medical Research Methodology (24). p.138

Vulnerability of Thalamic Nuclei at CSF Interface During the Entire Course of Multiple Sclerosis
Koubiyr, I., Yamamoto, T., Blyau, S., Kamroui, R.A., Mansencal, B., Planche, V., Petit, L., Saranathan, M., Casey, R., Ruet, A., et al. (2024). Neurol Neuroimmunol Neuroinflamm (11). p.e200222

Simulation of acquisition shifts in T2 Flair MR images to stress test AI segmentation networks
Christiane Posselt, Mehmet Yigit Avci, Mehmet Yigitsoy, Patrick Schünke, Christoph Kolbitsch, Stefanie Remmele (2024). Journal of Medical Imaging

Big Multiple Sclerosis Data network: an international registry research network
Glaser, A., Butzkueven, H., van der Walt, A., Gray, O., Spelman, T., Zhu, C., Trojano, M., Iaffaldano, P., Battaglia, M.A., Lucisano, G., et al. (2024). J Neurol

High-Efficacy Therapy Discontinuation vs Continuation in Patients 50 Years and Older With Nonactive MS
Jouvenot, G., Courbon, G., Lefort, M., Rollot, F., Casey, R., Le Page, E., Michel, L., Edan, G., de Seze, J., Kremer, L., et al. (2024). JAMA Neurology

Highly Effective Therapies as First-Line Treatment for Pediatric-Onset Multiple Sclerosis
Benallegue, N., Rollot, F., Wiertlewski, S., Casey, R., Debouverie, M., Kerbrat, A., De Seze, J., Ciron, J., Ruet, A., Labauge, P., et al. (2024). JAMA Neurol (81). p.273–282

The Response Study: A French registry on pregnancy in women with MS and related disorders and their children up to 6 years-Protocol, recruitment status, and baseline characteristics
Vukusic, S., Bourre, B., Casey, R., Deiva, K., Guennoc, A.-M., Lebrun-Frenay, C., Leray, E., Rollot, F., Benyahya, L., Girod, C., et al. (2024). Mult Scler (30). p.216–226

Real-life study to assess effectiveness and safety of eculizumab in patients with neuromyelitis optica spectrum disorders in France: protocol for ECUP4, an observational study
Marignier, R., Laplaud, D., Zéphir, H., Papeix, C., Leray, E., Amri, E., Piotaix, M., and de Sèze, J. (2024). Front. Neurol. (14).

Risk factors and prognosis of orotracheal intubation in aquaporin-4-IgG neuromyelitis optica spectrum disorder attacks
Januel, E., Brochard, V., Le Guennec, L., Maillart, E., Louapre, C., Lubetzki, C., Weiss, N., Demeret, S., and Papeix, C. (2024). Ann Intensive Care (14). p.4

LymphoTEC: a Retrospective Real-World Study on Lymphocyte Reconstitution After Lymphopenia in Patients with Multiple Sclerosis Treated with Dimethyl Fumarate in France
de Sèze, J., Labauge, P., Liblau, R., Martinez, M., Moreau, T., Suchet, L., Vermersch, P., Vukusic, S., Mathey, G., Michel, L., et al. (2025). Adv Ther (42). p.1760–1782

Causal Inference in Presence of Intra-Patient Correlation due to Repeated Measurements of Exposure and Outcome in Longitudinal Settings
Gavoille, A., Rollot, F., Casey, R., Vukusic, S., Rabilloud, M., and Subtil, F. (2025). Stat Med (44). p.e70037

Assessing the Risk of Relapse After In Vitro Fertilization in Women With Multiple Sclerosis
Mainguy, M., Casey, R., Vukusic, S., Lebrun-Frenay, C., Berger, E., Kerbrat, A., Al Khedr, A., Bourre, B., Ciron, J., Clavelou, P., et al. (2025). Neurol Neuroimmunol Neuroinflamm (12). p.e200371

Blood immunophenotyping of multiple sclerosis patients at diagnosis identifies a classical monocyte subset associated to disease evolution
Rodriguez, S., Couloume, L., Ferrant, J., Vince, N., Mandon, M., Jean, R., Monvoisin, C., Leonard, S., Le Gallou, S., Silva, N.S.B., et al. (2025). Front. Immunol. (15).

Association between education level and access to disease-modifying treatment in patients with multiple sclerosis in France
Lefort, M., Dejardin, O., Berger, E., Camdessanché, J.-P., Ciron, J., Clavelou, P., De Sèze, J., Debouverie, M., Heinzlef, O., Labauge, P., et al. (2025). Mult Scler (31). p.69–80

Natalizumab Versus Fingolimod in Patients with Relapsing-Remitting Multiple Sclerosis: A Subgroup Analysis From Three International Cohorts
Sharmin, S., Lefort, M., Andersen, J.B., Leray, E., Horakova, D., Havrdova, E.K., Alroughani, R., Izquierdo, G., Ozakbas, S., Patti, F., et al. (2021). CNS Drugs (35). p.1217–1232

Estimation of sample size in randomized controlled trials in multiple sclerosis studying annualized relapse rates: A systematic review
Poncet-Megemont, L., Pereira, B., Rollot, F., Sormani, M.P., Clavelou, P., and Moisset, X. (2021). Mult Scler p.13524585211052400

Risk Factors and Time to Clinical Symptoms of Multiple Sclerosis Among Patients With Radiologically Isolated Syndrome
Lebrun-Frénay, C., Rollot, F., Mondot, L., Zephir, H., Louapre, C., Le Page, E., Durand-Dubief, F., Labauge, P., Bensa, C., Thouvenot, E., et al. (2021). JAMA Netw Open (4). p.e2128271

A meta-analysis comparing first-line immunosuppressants in neuromyelitis optica
Giovannelli, J., Ciron, J., Cohen, M., Kim, H.-J., Kim, S.-H., Stellmann, J.-P., Kleiter, I., McCreary, M., Greenberg, B.M., Deschamps, R., et al. (2021). Ann Clin Transl Neurol (8). p.2025–2037

Cumulative effects of therapies on disability in relapsing multiple sclerosis
Rollot, F., Casey, R., Leray, E., Debouverie, M., Edan, G., Wiertlewski, S., Vukusic, S., and Laplaud, D.-A. (2021a). Mult Scler (27). p.1760–1770

Determinants of therapeutic lag in multiple sclerosis
Roos, I., Leray, E., Frascoli, F., Casey, R., Brown, J.W.L., Horakova, D., Havrdova, E.K., Debouverie, M., Trojano, M., Patti, F., et al. (2021a). Mult Scler (27). p.1838–1851

Early treatment delays long-term disability accrual in RRMS: Results from the BMSD network
Iaffaldano, P., Lucisano, G., Butzkueven, H., Hillert, J., Hyde, R., Koch-Henriksen, N., Magyari, M., Pellegrini, F., Spelman, T., Sørensen, P.S., et al. (2021). Mult Scler (27). p.1543–1555

Effects of High- and Low-Efficacy Therapy in Secondary Progressive Multiple Sclerosis
Roos, I., Leray, E., Casey, R., Horakova, D., Havrdova, E., Izquierdo, G., Madueño, S.E., Patti, F., Edan, G., Debouverie, M., et al. (2021b). Neurology (97). p.e869–e880

The effectiveness of natalizumab vs fingolimod-A comparison of international registry studies
Andersen, J.B., Sharmin, S., Lefort, M., Koch-Henriksen, N., Sellebjerg, F., Sørensen, P.S., Hilt Christensen, C.C., Rasmussen, P.V., Jensen, M.B., Frederiksen, J.L., et al. (2021). Mult Scler Relat Disord (53). p.103012

Oral nomegestrol acetate and transdermal 17-beta-estradiol for preventing post-partum relapses in multiple sclerosis: The POPARTMUS study
Vukusic, S., Ionescu, I., Cornu, C., Bossard, N., Durand-Dubief, F., Cotton, F., Durelli, L., Marignier, R., Gignoux, L., Laplaud, D.-A., et al. (2021a). Mult Scler (27). p.1458–1463

Effects of Age and Disease Duration on Excess Mortality in Patients With Multiple Sclerosis From a French Nationwide Cohort
Rollot, F., Fauvernier, M., Uhry, Z., Vukusic, S., Bossard, N., Remontet, L., Leray, E., and OFSEP Investigators (2021b). Neurology (97). p.e403–e413

MRI to detect and localize the area postrema in multiple sclerosis: The role of 3D-DIR and 3D-FLAIR
Farges, V., Hannoun, S., Benini, T., Marignier, R., and Cotton, F. (2021). J Neuroimaging (31). p.701–705

Clinical failure of natalizumab in multiple sclerosis: Specific causes and strategy
Guery, D., Marignier, R., Durand-Dubief, F., Lavie, C., Pique, J., Guerrier, O., and Vukusic, S. (2021). Rev Neurol (Paris) p.S0035-3787(21)00583-X

Untreated patients with multiple sclerosis: A study of French expert centers
Moisset, X., Fouchard, A.-A., Pereira, B., Taithe, F., Mathey, G., Edan, G., Ciron, J., Brochet, B., De Sèze, J., Papeix, C., et al. (2021). Eur J Neurol (28). p.2026–2036

Update on brain MRI for the diagnosis and follow-up of MS patients
Brisset, J.-C., Vukusic, S., Cotton, F., and Imaging Group of the “Observatoire francais de la sclérose en plaques” (2021). Presse Med (50). p.104067

Aquaporin 4 distribution in the brain and its relevance for the radiological appearance of neuromyelitis optica spectrum disease
Ameli, R., Guttmann, C.R.G., Prieto, J.C., Rollot, F., Palotai, M., Vukusic, S., Marignier, R., Cotton, F., Group Members for OFSEP Imaging Working Group, COPIL of OFSEP, et al. (2021). J Neuroradiol (48). p.170–175

Comparison of SimoaTM and EllaTM to assess serum neurofilament-light chain in multiple sclerosis
Gauthier, A., Viel, S., Perret, M., Brocard, G., Casey, R., Lombard, C., Laurent-Chabalier, S., Debouverie, M., Edan, G., Vukusic, S., et al. (2021a). Ann Clin Transl Neurol (8). p.1141–1150

MRI findings in blinded trials should be available to treating physicians - Yes
Vukusic, S., and Lebrun-Frenay, C. (2021). Mult Scler (27). p.812–813

Comparison of SimoaTM and EllaTM to assess serum neurofilament‐light chain in multiple sclerosis
Gauthier, A., Viel, S., Perret, M., Brocard, G., Casey, R., Lombard, C., Laurent‐Chabalier, S., Debouverie, M., Edan, G., Vukusic, S., et al. (2021b). Ann Clin Transl Neurol (8). p.1141–1150

Assessing long-term effectiveness of MS treatment - a matter of debate
Trojano, M., and Iaffaldano, P. (2021). Nat Rev Neurol (17). p.197–198

Pregnancy with multiple sclerosis
Vukusic, S., Michel, L., Leguy, S., and Lebrun-Frenay, C. (2021b). Rev Neurol (Paris) (177). p.180–194

Diagnostic value of bright spotty lesions on MRI after a first episode of acute myelopathy
Rabasté, S., Cobo-Calvo, A., Nistiriuc-Muntean, V., Vukusic, S., Marignier, R., Cotton, F., and OFSEP, NOMADMUS Study Group (2021). J Neuroradiol (48). p.28–36

Clinical Features and Risk of Relapse in Children and Adults with Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease
Cobo-Calvo, A., Ruiz, A., Rollot, F., Arrambide, G., Deschamps, R., Maillart, E., Papeix, C., Audoin, B., Lépine, A.F., Maurey, H., et al. (2021). Ann Neurol (89). p.30–41

Relapses in Patients Treated with High-Dose Biotin for Progressive Multiple Sclerosis
Mathais, S., Moisset, X., Pereira, B., Taithe, F., Ciron, J., Labauge, P., Dulau, C., Laplaud, D., De Seze, J., Pelletier, J., et al. (2021). Neurotherapeutics (18). p.378–386

Treatment Switching and Discontinuation Over 20 Years in the Big Multiple Sclerosis Data Network
Hillert, J., Magyari, M., Soelberg Sørensen, P., Butzkueven, H., Van Der Welt, A., Vukusic, S., Trojano, M., Iaffaldano, P., Pellegrini, F., Hyde, R., et al. (2021). Front Neurol (12). p.647811

Efficacy and Safety of Teriflunomide in Multiple Sclerosis across Age Groups: Analysis from Pooled Pivotal and Real-world Studies
Oh, J., Vukusic, S., Tiel-Wilck, K., Inshasi, J.S., Rog, D., Baker, D.P., Pyatkevich, Y., Poole, E.M., and Vermersch, P. (2021). J Cent Nerv Syst Dis (13). p.11795735211028780

Women’s Health in Multiple Sclerosis: A Scoping Review
Ross, L., Ng, H.S., O’Mahony, J., Amato, M.P., Cohen, J.A., Harnegie, M.P., Hellwig, K., Tintore, M., Vukusic, S., and Marrie, R.A. (2021). Front Neurol (12). p.812147