Description of the OFSEP sample collection on 15 June 2019

The OFSEP collection is composed of samples taken from biological cohorts patients (OFSEP kit: blood and urine mandatory, cerebrospinal fluid (CSF) and faeces optional) and from HD cohort patients (blood sample).

Biological cohorts include radiologically isolated syndromes (RIS), clinically isolated syndromes (CIS), relapsing-remitting MS patients (RRMS) untreated, primary progressive MS patients (PPMS) untreated, related neurological syndromes (NMOSD), acute disseminated encephalomyelitis (ADEM) and progressive multifocal leukoencephalopathy (LEMP).

Patients included in HD cohort are RRMS, secondary progressive MS (SPMS) or PPMS.

On 15 June 2019, samples have been taken from 1,327 patients of biological cohorts and 1,458 patients of HD cohort, totaling 48,835 aliquot biological samples. Samples are stored in 22 biological resource centers.

Patients Patient number Blood* PBMC** Urine CSF*** Faeces
RIS 100 100 100 93 53 3
CIS 547 547 531 500 369 11
RRMS 1327 1327 183 179 124 21
SPMS 220 220 10 8 5 0
PPMS 282 282 197 179 134 12
NMOSD 286 286 283 235 26 3
ADEM 17 17 17 13 3 0
PML 6 6 6 6 1 0

* serum, EDTA plasma, DNA

** PBMC: peripheral blood mononuclear cells

*** CSF, cells from CSF